APECED: Is this a model for failure of T-cell and B-cell tolerance?
APECED and IPEX syndromes show similarities in the clinical presentations and immunological alterations, mainly regarding regulatory T-cells function.T-cell defect may lead to tissue destruction chiefly in endocrine organs.Besides, APECED is characterized by high-titer antibodies against a wide variety of cytokines, that could partly be responsible